West Ham left-back Aaron Cresswell could be in line to make his full international debut for England against Spain in Tuesday night's friendly.
The 26-year-old Hammers defender received his first England call-up for the November international break, and may press for minutes at Wembley given Southampton's Ryan Bertrand sat out training on Tuesday while Tottenham's Danny Rose is set to be rested.
The FA confirmed that England and Manchester United captain Wayne Rooney would join Bertrand in sitting out of training on Monday, with both players suffering "minor issues".
Should Southgate follow through with his original plans and decide to rest Spurs wing-backs Rose and Kyle Walker, that would leave Cresswell as the only recognised left-back left in the Three Lions squad for Tuesday's clash against La Roja.
Cresswell has missed the majority of the Premier League season through injury, having suffered a serious knee problem in July.
But the full-back has worked his way back into contention for the Hammers and successfully caught Southgate's eye, leading to his first senior international call up.
Cresswell said of his call-up last week: "The manager has been fantastic. To come here and train with some of the world-class players who are here is great to be a part of.
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"When you first start playing football, every boy wants to represent their country, and for me to do that would be a proud moment for me and my family."
